UCR

Department of Entomology



Faculty


Anandasankaentomologyr Ray

Assistant Professor of Entomology

Location: Genomics 2234B
Tel: (951) 827-5998
E-mail: anand.ray@ucr.edu

 

Former Institution

 Yale

Degrees

Ph.D. Molecular, Cellular and Developmental Biology 2005- Yale University

Awards

2006 - Polak Young Investigator Award in recognition of innovative research, Association of Chemoreception Sciences ACHEMS
2005 - John Spangler Nicholas Prize for outstanding doctoral candidate in Experimental Zoology, Yale University

 

Research Area

 

  • Ray Lab Website The main focus of this laboratory is to understand the molecular, neuronal and physiological basis of insect chemoreception and behavior. Most insects can detect and discriminate between a wide variety of odorants which is critical for a number of behaviors like finding food, mating, and oviposition. Odor molecules are detected by 7-transmembrane Odor Receptor proteins present on the surface of neurons in the olfactory organs. A large family of 60 Odor receptor (Or) genes was first identified in the fruit fly Drosophila melanogaster,which subsequently enabled the identification of similar families from genomes of several other insect species. The odor responses of individual odor receptors can be analyzed in great detail using an array of powerful molecular, genetic, bioinformatic and physiological means. Our lab will employ these approaches to address a number of important problems in entomology and neuroscience.
  • The molecular basis of olfaction in insect vectors of disease Insects like mosquitoes, tsetse flies, sand flies, house flies and ticks carry a large number of debilitating diseases like malaria, yellow fever, dengue, lymphatic filariasis, river blindness, african sleeping sickness, chagas disease, plague, west nile virus and typhus. Many insect vectors of disease find their human hosts through the sense of smell. We will study the function of odor receptor genes from these species to better understand the molecular basis of insect-host attraction. 
  • The molecular basis of olfaction in agricultural pests A large amount of agricultural crops and stored produce are consumed by insects like flies, moths and beetles. Many of these agricultural pests locate their food using olfactory cues. We will study the function of odor receptor genes from these insects to better understand the molecular basis of host attraction.
  • A laboratory based molecular approach to insect pest control Identification of odor receptors that guide insect - host and insect - insect interactions will provide us with new opportunities in pest control. We will employ high-throughput laboratory based functional assays to identify volatile compounds that can activate, inhibit or block odor receptors very efficiently. These compounds will be tested for behavior modifying effects and for usefulness as trapping agents, repellents, or masking agents.
  • Analysis of neuronal circuits that underlie odor guided behaviorsVery little is known about neuronal circuits in the central nervous system that give rise to specific odor guided behaviors. Our lab is interested in developing novel methods to analyze activity of neuronal circuits in the insect brain.

Publications

 

2012          Sim, C. K., Perry, S., Tharadra, S. K., Lipsick, J. S., and Ray, A. Epigenetic regulation of olfactory receptor gene expression by the Myb–MuvB/dREAM complex. Genes and Development, 26,  2483-2498. (* Cover of Nov 15th issue)

2012          Zhou, X., Slone, J.D., Rokas, A., Berger, S.L., Liebig, J. Ray, A., Reinberg, D.,and Zwiebel, L.J. Phylogenetic and Transcriptomic Analysis of Chemosensory Receptors in a Pair of Divergent Ant Species Reveals Sex-Specific Signatures of Odor Coding. PLoS Genet, 8(8): e1002930.

2011          Turner, S. L., Li, N., Guda, T., Githure, J., Carde, R. T., and Ray, A. Ultra-prolonged activation of CO2-sensing neurons disorients mosquitoes. Nature, 474, 87–91. (* Cover of June 3rd issue)

2011          Dahanukar, A., and Ray, A. Courtship, Aggression and Avoidance; Pheromones, Receptors and Neurons for Social Behaviors in Drosophila. Fly, 1;5(1):58-63. (Invited Review)

2011          Tom, W., deBruyne, M., Haehnel, M., Carlson, J.R., and Ray, A. Disruption of Olfactory Receptor Neuron Patterning in Scutoid mutant Drosophila. Molecular and Cellular Neuroscience. 46(1):252-61.


Turner SL and Ray A. (2009) Modification of CO2 avoidance behaviour in Drosophila by inhibitory odorants. Nature 461, 277-281.

Fuss SH. and Ray A. (2009) Mechanisms of odorant receptor gene choice in Drosophila and vertebrates. Molecular and Cellular Neuroscience 41(2009) 101-112.

Tichy A., Ray A., and Carlson JR (2008) A new Drosophila POU gene, pdm3, acts in odor receptor expression and axon targeting of olfactory neurons. Journal of Neuroscience July 9, 28, 7121-7129.

Ray A., van Naters WvdG, and Carlson JR (2008) A Regulatory Code for Neuron-Specific Odor Receptor Expression. PLoS Biology 6(5): e125 doi:10.1371/journal.pbio.0060125.

Ray, A., van der Goes van Naters, W., Shiraiwa, T., and Carlson, J. R. (2007). Mechanisms of odor receptor gene choice in Drosophila. Neuron 53, 353-369
 
 
 
 


General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

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Dept of Entomology Information

417 Entomology Bldg.

Fax: (951) 827-3086
Prospective Grad Students: (800) 735-0717
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